منابع مشابه
Phase-controlled, speckle-free holographic projection with applications in precision optogenetics.
Holographic speckle is a major impediment to computer-generated holographic (CGH) projections in applications ranging from display, optical tweezers, and machining to optogenetic neural control. We present an iterative phase retrieval algorithm that allows the projection of amplitude-controlled speckle-free one-dimensional patterns with a high degree of pattern uniformity. The algorithm, termed...
متن کاملCardiac optogenetics.
Optogenetics is an emerging technology for optical interrogation and control of biological function with high specificity and high spatiotemporal resolution. Mammalian cells and tissues can be sensitized to respond to light by a relatively simple and well-tolerated genetic modification using microbial opsins (light-gated ion channels and pumps). These can achieve fast and specific excitatory or...
متن کاملOptogenetics 3.0
Optogenetic methods use light to modulate the activities of target cells in vivo. By improving inter- and intracellular trafficking of light-sensitive switch proteins called opsins, Gradinaru et al. (2010) have developed a new generation of optogenetic tools capable of regulating the activity of targeted neurons with exquisite precision and efficiency.
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I was fascinated by the acute and insightful observations of my mentor, Coby Schal, on how male cockroaches pursue females in the forest (Science 215, 1405–1407). Later, at Tsing Hua University, in trying to understand how the brain controls sexual behavior and reproduction, we serendipitously discovered that juvenile hormone synthesis in cockroaches is regulated by NMDA receptors. Knowing the ...
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Optogenetics as developed by Dr. Karl Deisseroth and others has been a transformative technology in the area of neuroscience. By stimulating genetically-modified neurons with visible light, modulation of the ionic conduction across the cell membrane can be achieved with very high specificity and precise temporal control. Despite the major influence of this technique, its scope is limited by its...
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ژورنال
عنوان ژورنال: Nature Methods
سال: 2015
ISSN: 1548-7091,1548-7105
DOI: 10.1038/nmeth.3705